体内淋巴细胞微核形成与肺癌个体易感性的研究

doi:10.3969/j.issn.1004-616x.2001.01.007

Abstract

Abstract: Purpose : To investigate the association of the in vivo micronucleus formation in lymphocytes of human peripheral blood with lung cancer. Methods : Case - cont rol study included 95 patient s with lung cancer and 90 cont rols. Slides were prepared by the in vivo micronucleus test in capillary blood lymphocytes. Results : Spontaneous and induced by smoking micronucleus f requencies (MNF) in lung cancer patient s ( 0. 87 ‰ and 1. 64 ‰) are significantly higher than those in cont rols(0. 47 ‰and 0. 76 ‰) ( P < 0. 05 and P < 0. 01) . Conclusion : Patient s with lung cancer were susceptible to mutagens ; In this study we confirmed first that the in vivo micronucleus formation in lymphocyte of peripheral blood is an excellent biomarker in assessing individual cancer susceptibility , persons with 1 ‰and 3 ‰of MNF had an increase of 5. 5 - fold and 21. 9 - fold higher relative risk for lung cancer.

Key words: lung cancer, micronucleus, genetic susceptibility

CLC Number:

R73 - 31

XUE Kai - xian, XU Lin, MA Kuo - jia, WU Jian - zhong, CHEN Sen - qing.. MICRONUCLEUS FORMATION IN VIVO IN LYMPHOCYTES OF HUMAN PERIPHERAL BLOOD AND INDIVIDUAL SUSCEPTIBILTY TO LUNG CANCER[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2001, 13(1): 20-022.

[1]	SHI Wenjing, ZHANG Jiqianzhu, ZHU Jiangbo, ZHANG Xiaofang, WANG Ruina, DAI Xiaoyu, REN Lijun, TIAN Yijun. Evaluation of genotoxicity of diphenhydramine hydrochloride and caffeine compound [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(2): 149-153,157.
[2]	CAI Qi, GAO Deyu, SHI Jianfeng, YU Hao, HAN Yan, YANG Liu, ZHAO Lei, WANG Zhaoxu. Potential use of tree shrew as an animal model for the micronucleus test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 370-374,382.
[3]	LIU Xiaoxia, LI Weixia, LI Zhijia, SU Zhenjun, DUAN Xiaohui, HAN Weiwen, WANG Yunxiao, HE Xiaolei, Lu Linlin, JIA Jinhai. Correlations between glutathione peroxidase in serum and clinicopathological outcomes of advanced non-small cell lung cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 286-290,295.
[4]	WANG Xikai, MENG Qinghe, GAO Yanlu. miR-223-3p negatively regulated ECT2 to induce apoptosis in non-small cell lung cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(3): 187-192.
[5]	LU Xue, TIAN Xuelei, ZHAO Hua, CAI Tianjing, TIAN Mei, LIU Qingjie. Use of the micronucleus assay to estimate partial radiation exposure dose in vitro [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(3): 193-196.
[6]	ZHAO Junwei, HUA Chenfeng, SHANG Pingping, XIE Fuwei, LI Xiang. Induction of oxidative stress by arsenious acid As(Ⅲ) in A549 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 28-31.
[7]	ZHAO Hua, LU Xue, CAI Tianjing, TIAN Mei, LIU Qingjie. Effects of age and gender on formation of nucleoplasmic bridges in peripheral blood lymphocytes [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 48-52.
[8]	LIU Xiaoxia, LI Weixia, SU Zhenjun, JIA Jinhai, DUAN Xiaohui, LI Zhijia, HE Xiaolei, L Linlin, LIU Rui, WANG Yunxiao. Analyses of clinicopathological characteristics and curative effect of combined radio-with chemo-therapy for advanced non-small cell lung cancer with superoxide dismutase activity in serum [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(5): 350-354.
[9]	ZHANG Fan, LIU Guangchao, ZHANG Zhihan, LIU Fangfang, XIE Qi, GAO Shuqing. Effect of ketogenic diet on growth of subcutaneously transplanted human lung cancer in nude mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(4): 286-291.
[10]	CAO Yiyi, LIU Weiying, YOU Xinyue, XI Jing, Chen Ruixue, ZHANG Xinyu, LUAN Yang. In vitro genotoxicity evaluation of BDE-3, BDE-47 and BDE-209 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(1): 15-20,28.
[11]	WANG Quankai, XIE Guangyun, MA Shunpeng, GUO Haoran, WUHAN Baolier, SONG Jiayang, XU Jianning. Genotoxicity evaluation of glycidyl methacrylate [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(6): 479-482.
[12]	LI Ying, CHEN Xiaming, LI Hanrong, LUO Te. Genotoxicity of three kinds of electric mosquito repellents on plant root tip cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(5): 401-405,411.
[13]	YING Wei, WANG Xingyuan, JIANG Bo, ZHOU Wei. Association between polymorphisms in the miR-146a and susceptibility to non-small cell lung cancer [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(3): 222-226.
[14]	ZHU Jiawei, HU Xiao, WANG Xijun, WANG Yaru, FENG Lin, XIAO Ting. Clinical significance of Skp1 protein expression in non-small cell lung cancer tissues and peripheral blood [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(2): 89-95.
[15]	WU Wen, LI Ping, ZUO Ran, ZENG Qingbo, WU Desheng, XIE Ni, LONG Dingxin, YUAN Jianhui. Correlation between polymorphism of DNA methyltransferase 3B-149C>T and cancer risk:a meta-analysis [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(2): 102-110.

MICRONUCLEUS FORMATION IN VIVO IN LYMPHOCYTES OF HUMAN PERIPHERAL BLOOD AND INDIVIDUAL SUSCEPTIBILTY TO LUNG CANCER

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments